Richard G Knowles Selected Research

1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amine

9/2009

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

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Richard G Knowles Research Topics

Disease

8	Asthma (Bronchial Asthma) 01/2022 - 11/2007
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 04/2011
4	Inflammation (Inflammations) 01/2022 - 12/2012
3	Vomiting 04/2011 - 09/2009
2	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2021 - 04/2011
2	Pneumonia (Pneumonitis) 12/2012 - 04/2011
2	Nausea 04/2011 - 09/2009
1	Airway Remodeling 12/2012
1	Respiratory Hypersensitivity 12/2012
1	Hyperplasia 12/2012
1	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 04/2011
1	Pica (Geophagia) 09/2009
1	Hypersensitivity (Allergy) 01/2006
1	Neuralgia (Stump Neuralgia) 01/2006
1	Pain (Aches) 01/2006
1	Stroke (Strokes) 03/2005
1	Brain Ischemia (Cerebral Ischemia) 03/2005
1	Infarction (Infarctions) 03/2005
1	Ischemia 03/2005

Drug/Important Bio-Agent (IBA)

4	Phosphodiesterase 4 InhibitorsIBA 12/2012 - 09/2009
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2011
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 12/2012
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 03/2005
3	GW 274150IBA 12/2012 - 01/2006
2	SteroidsIBA 01/2022 - 11/2007
2	AllergensIBA 12/2012 - 11/2007
2	OvalbuminIBA 12/2012 - 04/2011
2	Pharmaceutical PreparationsIBA 12/2012 - 01/2011
2	EmeticsIBA 04/2011 - 09/2009
2	RoflumilastIBA 04/2011 - 09/2009
2	6- ((3- ((dimethylamino)carbonyl)phenyl)sulfonyl)- 8- methyl- 4- ((3- methyloxyphenyl)amino)- 3- quinolinecarboxamideIBA 04/2011 - 04/2011
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2011 - 04/2011
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2006 - 03/2005
1	C-Reactive ProteinIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Dinoprostone (PGE2)FDA Link 01/2021
1	Omalizumab (Xolair)FDA Link 01/2021
1	Prednisolone (Predate)FDA LinkGeneric 01/2021
1	ProstaglandinsIBA 01/2021
1	Prostaglandin D2IBA 01/2021
1	LeukotrienesIBA 01/2021
1	EicosanoidsIBA 01/2021
1	Leukotriene E4IBA 01/2021
1	IsoprostanesIBA 01/2021
1	Albuterol (Salbutamol)FDA LinkGeneric 01/2020
1	Bronchodilator Agents (Bronchodilators)IBA 01/2020
1	Volatile Organic CompoundsIBA 01/2020
1	vilanterolIBA 01/2013
1	CollagenIBA 12/2012
1	LipopolysaccharidesIBA 04/2011
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 09/2009
1	CilomilastIBA 09/2009
1	1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amineIBA 09/2009
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2009
1	PyransIBA 09/2009
1	AminesIBA 09/2009
1	RolipramIBA 09/2009
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2007
1	Protein Isoforms (Isoforms)IBA 01/2006
1	Analgesics (Analgesic Drugs)IBA 01/2006
1	Adenosine Triphosphate (ATP)IBA 03/2005
1	Glutamic Acid (Glutamate)FDA Link 03/2005

Therapy/Procedure

1	Therapeutics 12/2012
1	Anesthesia 09/2009